Niacinamide – A Little-Known, Yet Powerful Antioxidant Form of Vitamin B3


Just like nature packages every apple, carrot, blueberry, or cup of yogurt with a broad-spectrum of nutrients working in perfect biological synergy with one another.  So, do we…using nature as our guide, we created each 100% plant-based, HempMag nutritional supplement to have a wide variety of synergistic co-factors that work together in perfect synergy to create a supplement unlike any other you’ve ever experienced.


The topic of today’s article is a little known, yet powerful, antioxidant form of vitamin B3 we use in every supplement – known as niacinamide.


As a precursor of NAD+, NADH, NADP+, and NADPH, niacinamide plays an integral role in cellular metabolism, cellular proliferation, and the repair of damaged cells.  In addition to supporting a healthy metabolism, niacinamide serves the vital function of regenerating the body’s master antioxidant and detoxifying molecule, glutathione.


So, what makes this particular form of vitamin B3 so unique?  To answer that question, we need to look more closely at the other forms currently available.


There are four forms of vitamin B3 currently offered in nutritional supplements:


  • nicotinic acid – a natural, “acid” form of vitamin B3. Possesses mild antioxidant, anti-inflammatory properties (i.e. weaker than niacinamide); in doses greater than 20 mg can produce an uncomfortable red, flush covering the entire body, which lasts from 20-60 minutes.  For this reason, it’s usually not used in multivitamins as a source of vitamin B3.


  • niacinamide (nicotinamide) – a natural, “basic” form of vitamin B3. Possesses powerful antioxidant, anti-inflammatory properties. The most potent antioxidant of the four forms of vitamin B3; more powerful than vitamins C and E.  The form most commonly used in multivitamin supplements.


  • nicotinamide riboside – a natural, non-flushing form of vitamin B3. A newer, more expensive form of vitamin B3 touted as a superior precursor to NAD with questionable advantages.


  • inositol hexanicotinate – a natural, non-flushing form of vitamin B3. Possesses 30% lower absorption than other forms of niacin.


Common symptoms of vitamin B3 deficiency include:

  • fatigue
  • apathy
  • depression
  • anxiety
  • irritability
  • poor concentration
  • restlessness
  • skin problems



As a powerful antioxidant, niacinamide protects your cells against harmful reactive oxygen species (ROS) – also known as “free radicals”.  These highly reactive molecules can damage delicate cellular structures and are primary drivers in the body’s aging process.  In excess, free radicals accelerate the natural aging process.


A perfect example of free-radical damage is a sunburn, where the UV rays of the sun generate more free-radicals on the skin than the body can effectively neutralize – with antioxidants – resulting in a transient burn.  Wrinkling of the skin is another effect of cumulative free-radical damage, which can be increased by free-radical generators such as excessive sun exposure, air pollution, and heavy smoking and alcohol consumption.  Put them altogether without adequate antioxidant protection (e.g. plant-based diet, organic juices, nutritional antioxidants such as vitamin A, C, E, carotenes, copper, selenium, zinc) and you have a recipe for looking older than your years.


In addition to accelerating the aging process, unopposed free-radical generation can lead to cellular dysfunction and increases the risk of a number of diseases including depression, chronic fatigue, cognitive impairment, mitochondrial damage and dysfunction, metabolic syndrome, neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, atherosclerosis, and diabetes.



Niacinamide is neurotrophic, which is to say, it supports the health, growth, and repair of all cells in the brain and nervous system.  Through its innate antioxidant properties, and ability to regenerate the body’s master antioxidant, glutathione, niacinamide functions as a powerful antioxidant.  Coupled with its role in mitochondrial energy production, and a wide variety of cell nourishing and sustaining activities, niacinamide also possesses powerful neuroprotective activity. 


Like other neurotrophic vitamins and minerals (e.g. vitamin C, zinc) whose intake is often suboptimal or deficient due to a variety of factors including nutrient poor diets, excess refined sugar, increased requirements due to stress, and medication induced deficiencies – niacinamide in optimal amounts promotes the formation of new neurons (i.e. neurogenesis).

If you’re new to nutritional supplementation
 – or are a well-versed pro – I recommend starting with a well-balanced, multi-nutrient supplement that uses doses on the lower end of the spectrum, and focuses on nutrient synergy rather than mega-doses as featured in the HempMag line of high-performance brain supplements:


HempMag MOOD – for improved energy, mood, and well-being.


HempMag CALM – for greater calmness and relaxation.


HempMag FOCUS – for improved focus, alertness, and concentration.


HempMag COOLDOWN – for improved well-being, and inflammatory balance.



With our patent-pending, proprietary blend of “feel-good, brain nutrients“, ALL of our supplements provide the same core, “feel-good” elements – including the powerful antioxidant form of vitamin B3, niacinamide – which help you be the best YOU!


These “core nutrients”, which include organic hemp oil extract, magnesium (malate, taurinate), niacin-bound chromium, and seven B-vitamins are further enhanced with key synergistic nutrients specifically chosen for their scientifically validated benefits.  For example, boron is added to our FOCUS formula for its ability to improve focus and alertness, and selenium and molybdenum are added to our COOLDOWN formula for their powerful antioxidant benefits.



We view this as a sacred mission to serve the world with products that strengthen and provide nutritional support at the deepest level. Based on irrefutable science and grounded in nature — our products embody the values of our company — with unsurpassed quality, safety and effectiveness. Designed to provide our customers with profound nourishment while promoting a greater sense of vitality and well-being.





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