Slider

Promoting Balance and Harmony

In the Body’s Primary Neurotransmitter Systems

The HempMag product suite is a revolutionary dietary supplement designed to improve mood, focus, alertness, and working memory, support a healthy inflammatory response, and promote a calming effect on the brain and nervous system. Featuring supercritical CO2-extracted organic European hemp oil with highly-bioavailable magnesium in a patent-pending, nutrient blend.

Magnesium promotes balance in the body’s primary neurotransmitter systems. Your body’s “feel-good”, pleasure chemicals – endorphins, oxytocin, GABA, serotonin, and dopamine – ALL need sufficient magnesium for their optimal functioning1-7.

It’s been estimated that greater than 70% of the U.S. population has a magnesium deficiency, which contributes to depression, anxiety, chronic fatigue, learning and memory problems, muscle tension, headaches, ADD/ADHD, tics, tremors, muscle cramps, and insomnia.  Magnesium has been largely removed from most drinking water, processed foods, especially refined grains, in the Western world, contributing to a variety of neurological deficits and suboptimal brain function8-12.

Naturally-occurring phytocannabinoids in hemp oil support the body’s natural endocannabinoid system (ECS) – while the state-of-the-art, magnesium nutrient-blend strengthens the brain and nervous system by providing direct support and balance to all of your key neurotransmitter systems. It’s nutritional synergy at its finest.

The Endocannabinoid System (ECS)

CBD Receptors

For Homeostatic Balance

The ECS contains two cannabinoid receptors, CB1 and CB2, which are distributed throughout the brain and central nervous system, immune system, organs, and various tissues. These receptors bind to both endogenous endocannabinoids such as 2-AG and anandamide produced in the human body and exogenous phytocannabinoids obtained from plants such as hemp seeds (and stalk), chocolate, black pepper, clove, and other plants.

The ECS, its receptors (CB1, CB2), endogenous ligands (“endocannabinoids”), synthesizing and degrading enzymes, as well as transporter molecules, have been detected from the earliest stages of embryonic development and throughout pre- and postnatal development. During fetal development, the CB1 receptor plays a major role in brain development, regulating neural progenitor differentiation into neurons and glia and guiding axonal migration and synaptogenesis13. Breast milk is rich in the natural cannabinoid, 2-AG (with smaller amounts of anandamide) and is needed for a strong stable nervous system, immune system function, and healthy growth and development. Both 2-AG and anandamide (“ananda” meaning bliss in Sanskrit) are lipids derived from the natural fatty acid arachidonic acid, which mediate their effects by binding to CB1 and CB2 receptors14.

The role of the ECS in maintaining homeostasis or balance within the body can be best summarized as relax, rebalance, rejuvenate, and protect. The ECS modulates everything from embryological development to neural plasticity and neuroprotection. It also supports the immune system and promotes a healthy inflammatory response.

Endo/phytocannabinoids and magnesium are utilized by the body to maintain a state of balance (homeostasis) and well-being, but when the body’s needs or demands exceed production or intake, a variety of symptoms can emerge to alert you of a deficiency or imbalance. Symptoms such as sensitivity to stress, low energy and mood, sleep disturbances, inability to focus, and pain and inflammation are all indicators that your body may be running low on these natural rebalancing molecules.

As “feel-good, companion nutrients” – phytocannabinoids and our proprietary magnesium-nutrient blend function in perfect biological synergy – providing full-spectrum neurological support for improved mood, focus, stress tolerance, and optimal health and well-being.

Analysis of Organic Hemp Oil Extract

References

1. Standifer KM, Clark JA, Pasternak GW. Modulation of Mu1 opioid binding by magnesium: evidence for multiple receptor conformations. J Pharmacol Exp Ther. 1993 Jul;266(1):106-13.

2. Vink R, Nechifor M. Magnesium in drug abuse and addiction. Magnesium in the Central Nervous System [Internet]. Adelaide (AU): University of Adelaide Press; 2011.

3. Nechifor M. Magnesium in drug dependences. Magnes Res. 2008 Mar;21(1):5-15.

4. Eby GA, Eby KL, Murk H. Magnesium and major depression. In: Vink R, Nechifor M, editors. Magnesium in the Central Nervous System [Internet]. Adelaide (AU): University of Adelaide Press; 2011.

5. Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. Med Hypotheses. 2006;67(2):362-70.

6. Bourre JM. Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 1: micronutrients. J Nutr Health Aging. 2006 Sep-Oct;10(5):377-85.

7. Haider S, Sadir S, Naqvi F, Batool Z, Tabassum S, Khaliq S, Anis L, Sajid I, Haleem DJ. Magnesium treatment palliates noise-induced behavioral deficits by normalizing DAergic and 5-HTergic metabolism in adult male rats. Metab Brain Dis. 2016 Aug;31(4):815-25.

8. Rosanoff A, Weaver CM, Rude RK. Suboptimal magnesium status in the United States: are the health consequences underestimated? Nutr Rev. 2012 Mar;70(3):153-64.

9. Barnes Z. Magnesium, an invisible deficiency that could be harming your health. http://www.cnn.com/2014/12/31/health/magnesium-deficiency-health/index.html

10. Mark Hyman, MD. Magnesium: The Most Powerful Relaxation Mineral. http://www.huffingtonpost.com/dr-mark-hyman/magnesium-the-most-powerf_b_425499.html

11. Kelly Brogan, MD. A Woman’s Friend: Magnesium. http://kellybroganmd.com/magnesium-most-important-female-supplement/

12. Jacka FN, Overland S, Stewart R, Tell GS, Bjelland I, Mykletun A. Association between magnesium intake and depression and anxiety in community-dwelling adults: the Hordaland Health Study. Aust N Z J Psychiatry. 2009 Jan;43(1):45-52.

13. Fride E. Multiple roles for the endocannabinoid system during the earliest stages of life: pre- and postnatal development. J Neuroendocrinol. 2008 May;20 Suppl 1:75-81.

14. Pertwee, RG, et al. International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: Beyond CB1 and CB2. Pharmacol. Rev., 62 (2010), pp. 588-631.